2-THIOPHENEGLYOXYLIC ACID

PRODUCT IDENTIFICATION

CAS NO. 4075-59-6

2-THIOPHENEGLYOXYLIC ACID

EINECS NO. 223-794-2
FORMULA C6H4O3S
MOL WT. 156.16

H.S. CODE

 

TOXICITY

 
SYNONYMS 2-Thienyl glyoxylic acid; alpha-oxothiophen-2-acetic acid;
alpha-oxo-thiophen-2-essigsaeure (German); ácido -alpha-oxotiofen-2-acetico (Spanish); Acide alpha.-oxothiophene-2-acetique (French);
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to greenish crystalline powder
MELTING POINT 88 - 91 C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  

SOLVENT SOLUBILITY

 
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 
AUTOIGNITION

 

NFPA RATINGS Health: 3; Flammability: 0; Reactivity: 0
FLASH POINT  
STABILITY

Stable under ordinary conditions. Hygroscopic.

APPLICATIONS

Glyoxylic acid is the smallest alpha-keto acid which has a ketone group on the carbon atom next to the acid group. If the ketone group is on the second carbon next to the acid group, it is called beta-keto acid. Glyoxylic acid has dual functional compound with both carboxylic acid and aldehyde. One more example of small mole weight alpha-keto acid is pyruvic acid which has methyl branch. Glyoxylic acid is present in the body as the primary precursor of oxalic acid and as an intermediate in the conversion of glycolic acid to glycine. The metabolic pathway to convert fat to carbohydrateby in certain microorganisms and plants is called glyoxylate cycle. Glyoxylates, any salt, anion, or ester of glyoxylic acid, are important in biochemical research.

Pure glyoxylic acid is a liquid with melting point of -93 C and boiling Point of 111 C. Glyoxylic acid is formed in commerce by oxidation reaction of glycolic acid or by ozonolysis (oxidaton) and reduction of maleic acid. Ozonolysis which uses ozone is to cleave the alkene bonds. An example of ozonolysis in commerce is the production of odd carbon number carboxylic acids such as azelaic acid and pelargonic acid and simple carboxylic acids such as formic acid and oxalic acid.

Allantoin, active in skin-softening (keratolytic effect) and rapid cell regeneration by precipitating proteins on skin is the diureide of glyoxylic acid. In industrial field, it is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds. Applications filed includes aroma compounds, agrochemicals, pharmaceuticals, and polymers.

Thiophene, also known as thiofuran, is a cyclic compound containing four carbon atoms and one sulfur atom in the ring. Thiophene is an analog to furan and pyrrole where the sulfur atom is replaced by O and NH respectively. Thiophene is a toxic, flammable, and colorless liquid; insoluble in water (soluble in most organic solvents including alcohol and ether); melting at -38 C, boiling at 84 C. Thiophene is the simplest aromatic compound containing sulfur atom and it shares some similar chemical properties with benzene. The lone electron pairs on sulfur in the delocalized pi electron system does not exhibits the properties of thioethers but aromaticity. The sulfur atom is unreactive but the adjacent carbons are susceptible to attack by electrophiles. It is reactive toward sulfonation. In commercial thiophene can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. Thiophene and its derivatives exist in petroleum or coal. Thiophene derivatives are also found in natural plant pigments. Biotin, a water-soluble B-complex vitamin, is a reduced thiophene derivative. Thiophene moiety is found in ccphalothin antiboitics. Thiophene is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers. Organic conductive polymers are responsible for the important materials science for the application of polymer electro luminescence. 2-Thiopheneglyoxylic acid is used as an intermediate to manufacture pharmaceuticals, aroma compounds and pesticides.
SALES SPECIFICATION

APPEARANCE

yellow to greenish crystalline powder

ASSAY

95.0% min

WATER

0.5% max

TRANSPORTATION
PACKING

25kgs in carton

HAZARD CLASS 8 (Packing Group: II)
UN NO. 3261
OTHER INFORMATION
Hazard Symbols: C, Risk Phrases: 34, Safety Phrases: 26-27-28-36/37/39-45

PRICE INFORMATION

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